The 2-Minute Rule for thr77 login
The 2-Minute Rule for thr77 login
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The antibody is from purified rabbit serum by affinity purification by using sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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Overexpression of this gene has actually been observed in several tumors, which results in chromosome instability, and therefore may perhaps contribute to tumorigenesis. This protein was uncovered to affiliate with, and become involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a important role in promoting cell-cycle progression within the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two added splice variants were described but in depth nucleotide sequence information and facts isn't but offered.
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Blocking peptides are peptides that bind exclusively to the target antibody and block antibody binding. These peptide commonly incorporates the epitope acknowledged by the antibody.
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This manual outlines further possible optimization of mobile and immunoassay parameters to guarantee the very best benefits are...
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This information outlines even further doable optimization of mobile and immunoassay parameters to ensure the very best results are...
Antibodies bound to the blocking peptide no more bind to your epitope to the concentrate on protein. By evaluating the staining with the blocked antibody vs . the antibody by itself, you can see which staining is precise.
Target Info Cyclin E belongs into the very conserved cyclin family, whose associates are characterized by a dramatic periodicity in protein abundance through the mobile cycle. Cyclins function as regulators of CDK kinases. Different cyclins show distinct expression and degradation designs which lead on the temporal coordination of every mitotic occasion. Cyclin E forms a posh with and functions like a regulatory subunit of CDK2, whose action is required for mobile cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells development through S phase.
The measurement of protein phosphorylation is a useful tool for measuring the modulation of receptor activation by both antibodies...
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